CBD Claims with Clinical Studies
Dr. Bonni Goldstein, Cannabis physician: Pain from inflammation can and will affect all adults at some point in their lives, and for some, become chronic and interfere with a normal quality of life. Multiple studies have proven the anti-inflammatory benefits of phytocannabinoids and terpenoids, the compounds that abound in the cannabis plant. (Pertwee, 1999, Klein 2005, Nagarkatti 2009, Booz, 2011, Xiong 2012, Mecha 2013).
The plant cannabinoids have many different mechanisms of action in their anti-inflammatory properties, including the blockage of pro-inflammatory compounds that are made in the body as a result of injury or illness. CBDA, cannabidiolic acid, the raw non-psychoactive cannabinoid precursor to CBD, showed significant COX-2 enzyme blockage when compared to placebo, two NSAIDs and other cannabinoids. (Takeda 2008).
Dr. Ethan Russo and Dr. Geoffrey Guy, in their excellent 2005 study, report that the phytocanna- binoids work synergistically (the “entourage effect”) to provide balanced and nontoxic medicinal effects when compared with single molecule anti-inflammatories. (Russo and Guy, 2005).